Tag: CNS depression

Antihistamine Interactions with Other Sedating Medications: What You Need to Know

January 30 2026

Antihistamine Interactions with Other Sedating Medications: What You Need to Know

Combining first-generation antihistamines like Benadryl with other sedating drugs can cause dangerous CNS depression. Learn which medications to avoid, why second-gen options are safer, and how to protect yourself - especially if you're over 65.

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