Quinacrine is an older drug that you might still see in specific cases. It was one of the first synthetic antimalarials and later found uses against some intestinal infections and other niche problems. These days doctors don’t reach for it first, but it can have a role when other treatments fail or aren’t available.
Most commonly, quinacrine has been used for: malaria (historically), certain parasitic infections like resistant giardiasis, and a few special procedures in the past. If you hear about quinacrine now, it’s usually in the context of a second-line option or a historical discussion. Your doctor will only pick it when the benefits beat the risks or when alternatives aren’t working.
If a clinician prescribes quinacrine, they should explain why it’s chosen over more common drugs and what to watch for during treatment. Don’t assume it’s interchangeable with modern antimalarials or antibiotics — the situations and dosing differ.
Quinacrine can cause side effects that range from mild to serious. Expect things like nausea, headache, and skin changes. More severe reactions — mood changes, confusion, or significant allergic reactions — have been reported, especially at higher doses or with long use. If you notice yellowing of the skin, severe stomach upset, sudden mood shifts, or trouble breathing, stop taking the drug and call your doctor right away.
Pregnancy and breastfeeding are special cases. Some older reports raise concerns, so many providers avoid quinacrine for pregnant people unless there’s no safer option. Always tell your prescriber if you’re pregnant, planning pregnancy, or breastfeeding.
Also mention any other medicines you take. Drug interactions can change how a medicine works or raise the risk of side effects. Your prescriber should check your full medication list before starting quinacrine.
Labs or follow-up visits: depending on the reason it’s given, a doctor may want to check liver tests, blood counts, or simply meet you for a quick review. Keep those appointments and report side effects early — small problems are easier to manage than big ones.
How to get quinacrine: this is prescription-only in most places. Don’t self-medicate or buy from an unverified source. If your doctor prescribes it, use a trusted pharmacy and confirm the product matches the prescription.
Questions to ask your provider: Why is quinacrine the best choice here? How long will I take it? What side effects should I expect, and which ones need urgent care? Who do I call if I have a bad reaction?
Quinacrine still has a place in medicine, but it’s not a first-line everyday drug. If your doctor suggests it, get clear instructions and watch for side effects. When in doubt, ask — clear communication keeps treatment safe and effective.
