Wellbutrin is the brand name for bupropion. Doctors use it mainly for major depression and seasonal affective disorder, and as a tool to help people quit smoking. It works differently from common SSRIs, so many people report less sexual side effects and more energy or focus. That difference also brings a unique side effect profile you should know about.
Short answer: it can help, but it needs careful use. Below are the practical facts so you can talk to your doctor with confidence.
Wellbutrin is available as immediate-release (IR), sustained-release (SR), and extended-release (XL). A common start is 150 mg once daily for SR or XL. For depression, doctors may raise it to 150 mg twice daily (SR) or 300 mg once daily (XL). The usual maximum dose is 450 mg per day. Zyban (bupropion for smoking) often uses 150 mg once daily for 3 days, then 150 mg twice daily.
Take it in the morning to avoid insomnia. With SR, space doses at least 8 hours apart. XL is once daily. Keep a routine. If you miss a dose, skip it—don’t double up. Always follow your prescriber’s instructions.
Common side effects: dry mouth, headache, jitteriness, trouble sleeping, and sometimes mild weight loss. Blood pressure can rise, so check it if you have hypertension.
The main safety concern is seizure risk. That risk rises at higher doses and in people with a history of seizures, eating disorders (like bulimia), heavy alcohol use, or certain drug interactions. Tell your doctor about seizures, head injuries, or recent alcohol withdrawal.
Wellbutrin can trigger manic episodes in people with bipolar disorder. Don’t combine it with MAO inhibitors or other drugs that meaningfully raise the seizure threshold, such as tramadol or some stimulants, without medical advice. Alcohol can make side effects worse and increase seizure risk.
How quickly it works: some people feel a lift in 1–2 weeks, but full effects often take 4–6 weeks. Don’t stop suddenly—withdrawal can cause mood shifts and irritability. Plan a taper with your prescriber if you need to stop.
Pregnancy and breastfeeding: this needs a personalized discussion. Risks from untreated depression can be real, so weigh options with your provider. Wellbutrin is available as a generic, which lowers cost, but you still need a prescription.
Buying online: use only licensed pharmacies and require a prescription. Avoid sites that sell prescription drugs without verifying credentials.
What to ask your doctor: Is Wellbutrin right for my symptoms? Any reasons I shouldn’t take it (seizure risk, eating disorder, bipolar)? Which formulation is best for me? How will we monitor side effects? Asking these makes treatment safer and clearer.
If you notice severe problems—seizure, severe rash, chest pain, or suicidal thoughts—seek urgent medical care. For new agitation or mood swings, contact your prescriber quickly. Regular check-ins in the first weeks make a big difference.
