When working with Indinavir, a protease inhibitor prescribed for HIV infection. Also known as Crixivan, it blocks the viral protease enzyme and stops HIV from maturing into infectious particles. This drug is a cornerstone of antiretroviral therapy, the combination regimen that keeps viral load low and preserves immune function.
Understanding Indinavir starts with the virus it battles. HIV, human immunodeficiency virus attacks CD4 cells, weakening the immune system. Indinavir belongs to the protease inhibitors, a class of drugs that halt the final step of viral replication. By combining it with reverse‑transcriptase inhibitors and other agents, doctors create a potent regimen that reduces the chance of the virus rebounding.
Typical dosing is 800 mg taken twice daily on an empty stomach, usually 30 minutes before meals. The empty‑stomach rule matters because food can lower drug absorption by up to 60 %. Patients should keep a consistent schedule, use a pill organizer, and avoid grapefruit juice, which interferes with metabolism. Blood tests for kidney function are essential before starting, as Indinavir is cleared through the kidneys.
Side effects vary, but the most frequent complaints are kidney stones, high bilirubin, and lipodystrophy (fat redistribution). Kidney stones can be painful, so staying well‑hydrated—about 2–3 L of water daily—is a simple preventive step. Elevated bilirubin often shows up as a mild yellowing of the skin but rarely requires stopping the drug. Lipodystrophy may cause a change in body shape; lifestyle changes and switching to newer protease inhibitors can help.
Drug resistance is a real concern when adherence slips. Missing doses gives HIV a chance to mutate, producing strains that no longer respond to Indinavir. Resistance testing is recommended if the viral load rises despite treatment. Additionally, Indinavir interacts with several medications, including certain antibiotics, anti‑seizure drugs, and statins. Always review current meds with a pharmacist before adding new ones.
The collection of articles below dives deeper into each of these topics. You'll find practical comparisons of Indinavir with newer protease inhibitors, tips for managing side effects, guidance on safe online purchases of generic versions, and up‑to‑date information on resistance testing. Whether you're just starting therapy or looking for ways to fine‑tune your regimen, the posts ahead give you actionable insights you can apply right away.
